Loss of PLK2 induces acquired resistance to temozolomide in GBM via activation of notch signaling

BACKGROUND: Glioblastoma (GBM) is a lethal type of primary brain tumor with a median survival less than 15 months. Despite the recent improvements of comprehensive strategies, the outcomes for GBM patients remain dismal. Accumulating evidence indicates that rapid acquired chemoresistance is the majo...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Clin Cancer Res
Auteurs principaux: Alafate, Wahafu, Xu, Dongze, Wu, Wei, Xiang, Jianyang, Ma, Xudong, Xie, Wanfu, Bai, Xiaobin, Wang, Maode, Wang, Jia
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657349/
https://ncbi.nlm.nih.gov/pubmed/33176854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01750-4
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