Epitopes for Multivalent Vaccines Against Listeria, Mycobacterium and Streptococcus spp: A Novel Role for Glyceraldehyde-3-Phosphate Dehydrogenase

The glycolytic enzyme and bacterial virulence factor of Listeria monocytogenes, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH, Lmo2459), ADP-ribosylated the small GTPase, Rab5a, and blocked phagosome maturation. This inhibitory activity localized within the NAD binding domain of GAPDH at the N...

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Dettagli Bibliografici
Pubblicato in:Front Cell Infect Microbiol
Autori principali: Alvarez-Dominguez, Carmen, Salcines-Cuevas, David, Teran-Navarro, Héctor, Calderon-Gonzalez, Ricardo, Tobes, Raquel, Garcia, Isabel, Grijalvo, Santiago, Paradela, Alberto, Seoane, Asunción, Sangari, Felix J., Fresno, Manuel, Calvo-Montes, Jorge, Pérez Del Molino Bernal, I. Concepción, Yañez-Diaz, Sonsoles
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Cellular and Infection Microbiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657268/
https://ncbi.nlm.nih.gov/pubmed/33194812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.573348
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