Sorafenib suppresses growth and survival of hepatoma cells by accelerating degradation of enhancer of zeste homolog 2

Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes that regulate cancer cell growth and survival. It is overexpressed in hepatocellular carcinoma (HCC) with a clinical significance that remains obscure. Sorafenib,...

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Vydáno v:Cancer Sci
Hlavní autoři: Wang, Shanshan, Zhu, Yu, He, Hongyong, Liu, Jing, Xu, Le, Zhang, Heng, Liu, Haiou, Liu, Weisi, Liu, Yidong, Pan, Deng, Chen, Lin, Wu, Qian, Xu, Jiejie, Gu, Jianxin
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2013
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657235/
https://ncbi.nlm.nih.gov/pubmed/23421437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12132
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