Dsg2 Upregulation as a Rescue Mechanism in Pemphigus

In pemphigus vulgaris (PV), autoantibodies directed against the desmosomal cadherin desmoglein (Dsg) 3 cause loss of intercellular adhesion. It is known that Dsg3 interactions are directly inhibited by autoantibody binding and that Dsg2 is upregulated in epidermis of PV patients. Here, we investigat...

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Pubblicato in:Front Immunol
Autori principali: Sigmund, Anna M., Steinert, Letyfee S., Egu, Desalegn T., Bayerbach, Franziska C., Waschke, Jens, Vielmuth, Franziska
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655986/
https://ncbi.nlm.nih.gov/pubmed/33193387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.581370
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