Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance

Adoptive transfer of allogeneic natural killer (NK) cells is becoming a credible immunotherapy for hematological malignancies. In the present work, using an optimized expansion/activation protocol of human NK cells, we generate expanded NK cells (eNK) with increased expression of CD56 and NKp44, whi...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Calvo, Tania, Reina-Ortiz, Chantal, Giraldos, David, Gascón, María, Woods, Daniel, Asenjo, Judit, Marco-Brualla, Joaquín, Azaceta, Gemma, Izquierdo, Isabel, Palomera, Luis, Sánchez-Martínez, Diego, Marzo, Isabel, Naval, Javier, Vilches, Carlos, Villalba, Martín, Anel, Alberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655821/
https://ncbi.nlm.nih.gov/pubmed/33173077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76051-z
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