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Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability

Extracellular pH has been assumed to play little if any role in how bacteria respond to antibiotics and antibiotic resistance development. Here, we show that the intracellular pH of Escherichia coli equilibrates to the environmental pH following treatment with the DNA damaging antibiotic nalidixic a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Booth, James Alexander, Špírek, Mário, Lobie, Tekle Airgecho, Skarstad, Kirsten, Krejci, Lumir, Bjørås, Magnar
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655802/
https://ncbi.nlm.nih.gov/pubmed/33173044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76426-2
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