Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response

The ubiquitin system regulates the DNA damage response (DDR) by modifying histone H2A at Lys15 (H2AK15ub) and triggering downstream signaling events. Here, we find that phosphorylation of ubiquitin at Thr12 (pUbT12) controls the DDR by inhibiting the function of 53BP1, a key factor for DNA double-st...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Walser, Franziska, Mulder, Monique P.C., Bragantini, Benoît, Burger, Sibylle, Gubser, Tatiana, Gatti, Marco, Botuyan, Maria Victoria, Villa, Alessandra, Altmeyer, Matthias, Neri, Dario, Ovaa, Huib, Mer, Georges, Penengo, Lorenza
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655664/
https://ncbi.nlm.nih.gov/pubmed/33022275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.09.017
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