Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging

Injection of tissues with senescent cells induces changes that mimic aging, and this process is delayed in mice engineered to eliminate senescent cells, which secrete proinflammatory cytokines, including C-C motif chemokine ligand 2 (Ccl2). Circulating levels of Ccl2 correlate with age, but the impa...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Luciano-Mateo, Fedra, Cabré, Noemí, Baiges-Gaya, Gerard, Fernández-Arroyo, Salvador, Hernández-Aguilera, Anna, Elisabet Rodríguez-Tomàs, Elisabet, Arenas, Meritxell, Camps, Jordi, Menéndez, Javier A., Joven, Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655213/
https://ncbi.nlm.nih.gov/pubmed/33104522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.104154
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