Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis

Osteoarthritis (OA) is one of the most painful and widespread chronic degenerative joint diseases and is characterized by destructed articular cartilage and inflamed joints. Previously, our findings indicated that circular RNA ciRS-7 (ciRS-7)/microRNA 7 (miR-7) axis is abnormally expressed in OA, an...

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Podrobná bibliografie
Vydáno v:Aging (Albany NY)
Hlavní autoři: Zhou, Xindie, Li, Jin, Zhou, Yuanshuai, Yang, Zhicheng, Yang, Haoyu, Li, Dong, Zhang, Junjie, Zhang, Yi, Xu, Nanwei, Huang, Yong, Jiang, Lifeng
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655186/
https://ncbi.nlm.nih.gov/pubmed/33099538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103731
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