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Induction of Fibrogenic Phenotype in Human Mesenchymal Stem Cells by Connective Tissue Growth Factor in a Hydrogel Model of Soft Connective Tissue

Scar formation is the typical endpoint of wound healing in adult mammalian tissues. An overactive or prolonged fibrogenic response following injury leads to excessive deposition of fibrotic proteins that promote tissue contraction and scar formation. Although well-defined in the dermal tissue, the p...

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Detalhes bibliográficos
Publicado no:ACS Biomater Sci Eng
Main Authors: Zerdoum, Aidan B., Fowler, Eric W., Jia, Xinqiao
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654958/
https://ncbi.nlm.nih.gov/pubmed/33178886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsbiomaterials.9b00425
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