Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer

BACKGROUND: Resistance to chemotherapy is the most common cause of treatment failure in acute myeloid leukemia (AML) and the drug efflux pump ABCB1 is a critical mediator. Recent studies have identified promoter translocations as common drivers of high ABCB1 expression in recurrent, chemotherapy-tre...

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Pubblicato in:BMC Cancer
Autori principali: Williams, Mark S., Basma, Naseer J., Amaral, Fabio M. R., Williams, Gillian, Weightman, John P., Breitwieser, Wolfgang, Nelson, Louisa, Taylor, Stephen S., Wiseman, Daniel H., Somervaille, Tim C. P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654162/
https://ncbi.nlm.nih.gov/pubmed/33167906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07571-0
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