Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression

Limited clinical benefit has been demonstrated for chimeric antigen receptor (CAR) therapy of solid tumors, but coengineering strategies to generate so-called fourth-generation (4G) CAR-T cells are advancing toward overcoming barriers in the tumor microenvironment (TME) for improved responses. In la...

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Bibliografische gegevens
Gepubliceerd in:J Exp Med
Hoofdauteurs: Lanitis, Evripidis, Rota, Giorgia, Kosti, Paris, Ronet, Catherine, Spill, Aodrenn, Seijo, Bili, Romero, Pedro, Dangaj, Denarda, Coukos, George, Irving, Melita
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Rockefeller University Press 2020
Onderwerpen:
Technical Advances and Resources
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653685/
https://ncbi.nlm.nih.gov/pubmed/33156338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20192203
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