PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates

Most triacylglycerol-lowering fibrates have been developed in the 1960s–1980s before their molecular target, peroxisome proliferator-activated receptor alpha (PPARα), was identified. Twenty-one ligand-bound PPARα structures have been deposited in the Protein Data Bank since 2001; however, binding mo...

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Pubblicato in:iScience
Autori principali: Kamata, Shotaro, Oyama, Takuji, Saito, Kenta, Honda, Akihiro, Yamamoto, Yume, Suda, Keisuke, Ishikawa, Ryo, Itoh, Toshimasa, Watanabe, Yasuo, Shibata, Takahiro, Uchida, Koji, Suematsu, Makoto, Ishii, Isao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653058/
https://ncbi.nlm.nih.gov/pubmed/33205029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101727
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