Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates

Poor tissue penetration remains a major challenge for antibody-based therapeutics of solid tumors, but proper dosing can improve the tissue penetration and thus therapeutic efficacy of these biologics. Due to dose-limiting toxicity of the small molecule payload, antibody-drug conjugates (ADCs) are a...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Lu, Guolan, Nishio, Naoki, van den Berg, Nynke S., Martin, Brock A., Fakurnejad, Shayan, van Keulen, Stan, Colevas, Alexander D., Thurber, Greg M., Rosenthal, Eben L.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7652891/
https://ncbi.nlm.nih.gov/pubmed/33168818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19498-y
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