Isoprenoid-chained lipid EROCOC(17+4): a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography

In meso crystallization of membrane proteins relies on the use of lipids capable of forming a lipidic cubic phase (LCP). However, almost all previous crystallization trials have used monoacylglycerols, with 1-(cis-9-octadecanoyl)-rac-glycerol (MO) being the most widely used lipid. We now report that...

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Publicado no:Sci Rep
Main Authors: Ihara, Kentaro, Hato, Masakatsu, Nakane, Takanori, Yamashita, Keitaro, Kimura-Someya, Tomomi, Hosaka, Toshiaki, Ishizuka-Katsura, Yoshiko, Tanaka, Rie, Tanaka, Tomoyuki, Sugahara, Michihiro, Hirata, Kunio, Yamamoto, Masaki, Nureki, Osamu, Tono, Kensuke, Nango, Eriko, Iwata, So, Shirouzu, Mikako
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7652841/
https://ncbi.nlm.nih.gov/pubmed/33168855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76277-x
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