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The influence of cardiac output on propofol and fentanyl pharmacokinetics and pharmacodynamics in patients undergoing abdominal aortic surgery

Cardiac output (CO) is expected to affect elimination and distribution of highly extracted and perfusion rate-limited drugs. This work was undertaken to quantify the effect of CO measured by the pulse pressure method on pharmacokinetics and pharmacodynamics of propofol and fentanyl administrated dur...

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Bibliografske podrobnosti
izdano v:J Pharmacokinet Pharmacodyn
Main Authors: Bienert, Agnieszka, Sobczyński, Paweł, Młodawska, Katarzyna, Hartmann-Sobczyńska, Roma, Grześkowiak, Edmund, Wiczling, Paweł
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7652808/
https://ncbi.nlm.nih.gov/pubmed/32840723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-020-09712-1
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