PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort

BACKGROUND: Therapeutic inhibition of PCSK9 protects against coronary artery disease (CAD) and ischemic stroke (IS). The impact on other diseases remains less well characterized. METHODS: We created a genetic risk score (GRS) for PCSK9 using four single nucleotide polymorphisms (SNPs) at or near the...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Small, Aeron M., Huffman, Jennifer E., Klarin, Derek, Lynch, Julie A., Assimes, Themistocles, DuVall, Scott, Sun, Yan V., Shere, Labiba, Natarajan, Pradeep, Gaziano, Michael, Rader, Daniel J., Wilson, Peter W. F., Tsao, Philip S., Chang, Kyong-Mi, Cho, Kelly, O’Donnell, Christopher J., Casas, Juan P., Damrauer, Scott M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7652310/
https://ncbi.nlm.nih.gov/pubmed/33166319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239752
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