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Synthesis and biological screening of a library of macamides as TNF-α inhibitors
Thirty-five macamide analogues were synthesised by modifying the initial molecular structure. The resulting structures were confirmed using NMR and MS. Cytotoxicity and the anti-inflammatory activity of these synthetic macamides were evaluated in the THP-1 cell line. Preliminary biological evaluatio...
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| Publicado no: | RSC Med Chem |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7652002/ https://ncbi.nlm.nih.gov/pubmed/33479624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00208a |
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