SURG-41. BLOOD-BRAIN BARRIER DISRUPTION WITH HIGH-FREQUENCY ELECTROPORATION IN VIVO: A PRELIMINARY INVESTIGATION DEMONSTRATING THE EFFECTS OF VARIED PULSE WIDTHS AND INTRA-PHASE DELAYS

OBJECTIVE: Treatment of CNS disorders suffer from the inability to deliver large therapeutic agents to the brain parenchyma due to protection from the blood-brain barrier (BBB). High-frequency electroporation (HFE) employs a series of high voltage pulsed electric fields to disrupt the BBB and/or abl...

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Vydáno v:Neuro Oncol
Hlavní autoři: Lorenzo, Melvin, Thomas, Sean, Verbridge, Scott, Robertson, John, Rossmeisl, John, Davalos, Rafael
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Surgical Therapies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651310/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.887
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