TMOD-05. EXTRACRANIAL TUMORS INFLUENCE INTRACRANIAL RESPONSE TO IMMUNE CHECKPOINT INHIBITORS IN PRE-CLINICAL MODELS OF MELANOMA BRAIN METASTASIS

Melanomas frequently spread to the brain, with up to 75% of patients developing brain metastases. Treatment of metastatic melanoma has been revolutionized by the advent of immune checkpoint inhibitors (ICI) targeting PD-1 and CTLA-4. However, responses to ICI within the immune-specialized brain envi...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Nayyar, Naema, Singh, Mohini, Stocking, Jackson, Brehm, Michael, Brastianos, Priscilla
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Tumor Models
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651309/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.956
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