CTNI-61. PILOT STUDY OF REPEATED PLANNED GLUCARPIDASE FOLLOWING HIGH DOSE METHOTREXATE (HD-MTX) IN CNS LYMPHOMA (CNSL)

This study explores the repeated use of glucarpidase following HD-MTX in patients with CNSL. HD-MTX requires aggressive hydration and inpatient monitoring to prevent toxicity. Glucarpidase 50 units(u)/kg for delayed MTX clearance results in a reduction of systemic MTX levels without crossing the blo...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Schaff, Lauren, Lobbous, Mina, Sener, Ugur, Gavrilovic, Igor, Miller, Alexandra, Stone, Jacqueline, Piotrowski, Anna, Skakodub, Anna, Madzsar, Juli, Schumpp, Alyssa, Acosta, Edward, Ryan, Kevin, Carlow, Dean, DeAngelis, Lisa, Nabors, Louis, Grommes, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Clinical Trials: Non-Immunologic
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651121/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.227
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