TAMI-18. SINGLE-CELL SEQUENCING AND GENETIC LABELING TO CHARACTERIZE HYPOXIC GBM CELLS IN THEIR MICROENVIRONMENT

Glioblastoma (GBM) recurrence, arising from treatment-resistant hypoxic cells, is a major contributor to patient mortality. We have engineered GBM cell lines with a novel genetic reporter system (“HRE-UnaG”), which sensitively labels hypoxic cells with green fluorescence. Using murine GL261 HRE-UnaG...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Sattiraju, Anirudh, Marallano, Valerie, Ramakrishnan, Aarthi, Brusco, Concetta, Shen, Li, Wojcinski, Alexandre, Kesari, Santosh, Friedel, Roland H, Zou, Hongyan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651095/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.907
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