Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence

Iron deprivation activates mitophagy and extends lifespan in nematodes. In patients suffering from Parkinson’s disease (PD), PINK1-PRKN mutations via deficient mitophagy trigger iron accumulation and reduce lifespan. To evaluate molecular effects of iron chelator drugs as a potential PD therapy, we...

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Xehetasun bibliografikoak
Argitaratua izan da:Cells
Egile Nagusiak: Key, Jana, Sen, Nesli Ece, Arsović, Aleksandar, Krämer, Stella, Hülse, Robert, Khan, Natasha Nadeem, Meierhofer, David, Gispert, Suzana, Koepf, Gabriele, Auburger, Georg
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650593/
https://ncbi.nlm.nih.gov/pubmed/33023155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9102229
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