CSIG-02. R-RAS SUBFAMILY PROTEINS ELICIT DISTINCT PHYSIOLOGIC EFFECTS AND PHOSPHOPROTEOME ALTERATIONS IN NEUROFIBROMIN-NULL MPNST CELLS

Loss of the Ras GTPase-activating protein neurofibromin promotes the development of aggressive spindle cell neoplasms known as Malignant Peripheral Nerve Sheath Tumors (MPNSTs) in patients with the genetic disorder neurofibromatosis type 1 (NF1). Currently, the available chemotherapeutic regimens an...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Weber, Shannon, Brossier, Nicole, Prechtl, Amanda, Brosius, Stephanie, Barnes, Stephen, Wilson, Landon, Carroll, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Cell Signaling and Signaling Pathways
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650503/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.114
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