CTNI-05. NRG ONCOLOGY / RTOG 1119: PHASE II RANDOMIZED STUDY OF WHOLE BRAIN RADIOTHERAPY / STEREOTACTIC RADIOSURGERY WITH CONCURRENT LAPATINIB IN PATIENTS WITH BRAIN METASTASES FROM HER2-POSITIVE BREAST CANCER

Trastuzumab/pertuzumab improved outcomes for patients (pts) with HER2+ breast cancer. Increased survival coupled with limited blood-brain barrier (BBB) penetration of these agents apparently contributes to increased incidence of brain metastases (BM). Lapatinib (L) crosses the BBB and demonstrates a...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Ah Kim, In, Winter, Kathryn, Sperduto, Paul, De Los Santos, Jennifer, Peereboom, David, Ogunleye, Tomi, Boulter, Daniel, Cho, Kwan Ho, Shin, Kyung Hwan, Zoberi, Imran, Choi, Serah, Palmer, Joshua, Liem, Ben, Kim, Yong Bae, Anderson, Bethany, Thakrar, Anupama, Muanza, Thierry, Kim, Michelle, Choi, Doo Ho, White, Julia, Mehta, Minesh
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Clinical Trials: Non-Immunologic
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650417/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.172
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