CBIO-25. INTEGRATED MOLECULAR AND BH3 PROFILING OF THE INTRINSIC APOPTOTIC MACHINERY IDENTIFIES THERAPEUTIC VULNERABILITIES IN GLIOBLASTOMA

Resistance to apoptosis is a hallmark of cancer. However, the underlying molecular mechanisms of intrinsic-apoptotic resistance in glioblastoma (GBM) are largely unknown. Here we performed integrated molecular and functional characterization (via BH3 profiling) of the intrinsic apoptotic machinery i...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Fernandez, Elizabeth, Mai, Wilson, Bayley, Nicholas, Tse, Christopher, Liau, Linda, Cloughesy, Timothy, Letai, Anthony, Nathanson, David
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Cell Biology (Cell Cycle Regulation, DNA Repair/Modulation)
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650381/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.085
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