CTNI-13. UPDATES ON CLINICAL OUTCOMES AND TUMOR RECURRENCE PATTERNS OF A HUMAN PILOT STUDY ASSESSING EFFICACY OF BELINOSTAT (PXD-101) COMBINING WITH CHEMORADIATION IN TREATING GLIOBLASTOMA

INTRODUCTION: Glioblastoma (GBM) is highly aggressive with poor prognosis. Belinostat is a histone deacetylase inhibitor with blood–brain barrier permeability that has anti-GBM activity and may enhance effects of chemoradiation. Our institution conducted a clinical trial evaluating clinical efficacy...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Xu, Karen, Huang, Vicki, Ramesh, Karthik, Gurbani, Saumya, Schreibmann, Eduard, Weinberg, Brent, Sengupta, Soma, Voloschin, Alfredo, Holdhoff, Matthias, Barker, Peter, Kleinberg, Lawrence, Olson, Jeffrey, Shim, Hyunsuk, Shu, Hui-Kuo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Clinical Trials: Non-Immunologic
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650343/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.180
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