Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue Toxicity

The ectonucleoside triphosphate diphosphohydrolase (CD39)/5′ ectonuclotidase (CD73)-dependent purinergic pathway emerges as promising cancer target. Yet, except for own previous work revealing a pathogenic role of CD73 and adenosine in radiation-induced lung fibrosis, the role of purinergic signalin...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Meyer, Alina V., Klein, Diana, de Leve, Simone, Szymonowicz, Klaudia, Stuschke, Martin, Robson, Simon C., Jendrossek, Verena, Wirsdörfer, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649817/
https://ncbi.nlm.nih.gov/pubmed/33194619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.554883
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