FcRγ Gene Editing Reprograms Conventional NK Cells to Display Key Features of Adaptive Human NK Cells

Adaptive human natural killer (NK) cells display significantly enhanced responsiveness to a broad-range of antibody-bound targets through the engagement of CD16 compared to conventional NK cells, yet direct reactivity against tumor targets is generally reduced. Adaptive NK cells also display a disti...

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Veröffentlicht in:iScience
Hauptverfasser: Liu, Weiru, Scott, Jeannine M., Langguth, Emma, Chang, Helena, Park, Peter H., Kim, Sungjin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649287/
https://ncbi.nlm.nih.gov/pubmed/33205022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101709
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