Combinational Pretreatment of Colony-Stimulating Factor 1 Receptor Inhibitor and Triptolide Upregulates BDNF-Akt and Autophagic Pathways to Improve Cerebral Ischemia

Ki20227, a selective inhibitor of colony-stimulating factor 1 receptor (CSF1R), has been suggested to regulate microglia inflammatory function and neuronal synaptic plasticity. Triptolide (TP) pretreatment has neuroprotective effects through its anti-inflammatory and antiapoptotic features in ischem...

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Vydáno v:Mediators Inflamm
Hlavní autoři: Du, Xiaoxue, Gao, Feng, Chen, Shijia, Botchway, Benson O. A., Amin, Nashwa, Hu, Zhiying, Fang, Marong
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648715/
https://ncbi.nlm.nih.gov/pubmed/33192177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/8796103
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