Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo

Slit is a secreted protein that has a canonical function of repelling growing axons from the CNS midline. The full-length Slit (Slit-FL) is cleaved into Slit-N and Slit-C fragments, which have potentially distinct functions via different receptors. Here, we report that the BMP-1/Tolloid family metal...

Full description

Saved in:
Bibliographic Details
Published in:Development
Main Authors: Kellermeyer, Riley, Heydman, Leah M., Gillis, Taylor, Mastick, Grant S., Song, Minmin, Kidd, Thomas
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648596/
https://ncbi.nlm.nih.gov/pubmed/32994163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.196055
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items