Generation of a Hutchinson–Gilford progeria syndrome monkey model by base editing

Many human genetic diseases, including Hutchinson-Gilford progeria syndrome (HGPS), are caused by single point mutations. HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene. Base editors (BEs) composed of a cytidine deaminase fused...

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Pubblicato in:Protein Cell
Autori principali: Wang, Fang, Zhang, Weiqi, Yang, Qiaoyan, Kang, Yu, Fan, Yanling, Wei, Jingkuan, Liu, Zunpeng, Dai, Shaoxing, Li, Hao, Li, Zifan, Xu, Lizhu, Chu, Chu, Qu, Jing, Si, Chenyang, Ji, Weizhi, Liu, Guang-Hui, Long, Chengzu, Niu, Yuyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Higher Education Press 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647984/
https://ncbi.nlm.nih.gov/pubmed/32729022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-020-00740-8
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