Methylphenidate and Morphine Combination Therapy in a Rat Model of Chronic Pain

BACKGROUND: The incremental dose of opioids used in chronic pain management often leads to a reduced opioid analgesic effect, opioid misuse and addiction. Central dopamine dysfunction contributes to the chronicity of pain and a decreased opioid analgesic effect. Methylphenidate (MPH/Ritalin) enhance...

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Bibliographic Details
Published in:Anesth Analg
Main Authors: You, Zerong, Ding, Weihua, Doheny, Jason T, Shen, Shiqian, Yang, Jinsheng, Yang, Liuyue, Chen, Lucy, Zhu, Shengmei, Mao, Jianren
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7646954/
https://ncbi.nlm.nih.gov/pubmed/31206430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000004273
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