Detection of BRAF splicing variants in plasma-derived cell-free nucleic acids and extracellular vesicles of melanoma patients failing targeted therapy therapies

The analysis of plasma circulating tumour nucleic acids provides a non-invasive approach to assess disease burden and the genetic evolution of tumours in response to therapy. BRAF splicing variants are known to confer melanoma resistance to BRAF inhibitors. We developed a test to screen cell-free RN...

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Udgivet i:Oncotarget
Main Authors: Clark, Michael E., Rizos, Helen, Pereira, Michelle R., McEvoy, Ashleigh C., Marsavela, Gabriela, Calapre, Leslie, Meehan, Katie, Ruhen, Olivia, Khattak, Muhammad A., Meniawy, Tarek M., Long, Georgina V., Carlino, Matteo S., Menzies, Alexander M., Millward, Michael, Ziman, Melanie, Gray, Elin S.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7646833/
https://ncbi.nlm.nih.gov/pubmed/33216826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27790
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