DNA methylation profiling of CD04(+)/CD08(+) T cells reveals pathogenic mechanisms in increasing hyperglycemia: PIRAMIDE pilot study

BACKGROUND: DNA methylation can play a pathogenic role in the early stages of hyperglycemia linking homeostasis imbalance and vascular damage. MATERIAL AND METHODS: We investigated DNA methylome by RRBS in CD04(+) and CD08(+) T cells from healthy subjects (HS) to pre-diabetics (Pre-Diab) and type 2...

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Bibliographic Details
Published in:Ann Med Surg (Lond)
Main Authors: Benincasa, Giuditta, Franzese, Monica, Schiano, Concetta, Marfella, Raffaele, Miceli, Marco, Infante, Teresa, Sardu, Celestino, Zanfardino, Mario, Affinito, Ornella, Mansueto, Gelsomina, Sommese, Linda, Nicoletti, Giovanni Francesco, Salvatore, Marco, Paolisso, Giuseppe, Napoli, Claudio
Format: Artigo
Language:Inglês
Published: Elsevier 2020
Subjects:
Cross-sectional Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645316/
https://ncbi.nlm.nih.gov/pubmed/33194177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amsu.2020.10.016
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