S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression

A previous study on hepatoblastoma revealed novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex, including the tumor suppressor speckle-type BTB/POZ (SPOP). Moreover, the SPOP gene affected cell growth, and its S119N mutation was identified as a loss-of-function mutation...

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Udgivet i:Mol Ther Oncolytics
Main Authors: He, Weijing, Zhang, Jingjing, Liu, Baihui, Liu, Xiangqi, Liu, Gongbao, Xie, Lulu, He, Jiajun, Wei, Meng, Li, Kai, Ma, Jing, Dong, Rui, Ma, Duan, Dong, Kuiran, Ye, Mujie
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644817/
https://ncbi.nlm.nih.gov/pubmed/33209975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.09.008
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