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An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice
Interleukin-2 (IL-2) controls the homeostasis and function of regulatory T (Treg) cells and defects in the IL-2 pathway contribute to multiple autoimmune diseases. Although recombinant IL-2 therapy has been efficacious in certain inflammatory conditions, the capacity for IL-2 to also activate inflam...
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| Publicado no: | Sci Immunol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7643170/ https://ncbi.nlm.nih.gov/pubmed/32817295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aba5264 |
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