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Divergent serotype replacement trends and increasing diversity in pneumococcal disease in high income settings reduce the benefit of expanding vaccine valency

Streptococcus pneumoniae is a significant cause of otitis media, pneumonia, and meningitis. Only seven of the approximately 100 serotypes were initially included in the pneumococcal polysaccharide conjugate vaccine (PCV) in 2000 before it was expanded in subsequent years. Although the invasive pneum...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Løchen, Alessandra, Croucher, Nicholas J., Anderson, Roy M.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7643077/
https://ncbi.nlm.nih.gov/pubmed/33149149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75691-5
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