Inhibition of PI3K/Akt signaling suppresses epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail/GSK-3/beta-catenin pathway

BACKGROUND/AIMS: Patients with advanced hepatocellular carcinoma (HCC) have a poor prognosis due to the lack of effective systemic therapies. Epithelial-to-mesenchymal transition (EMT) is a pivotal event in tumor progression, during which cancer cells acquire invasive properties. In this study, we i...

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Bibliografiske detaljer
Udgivet i:Clin Mol Hepatol
Main Authors: Lee, Seulki, Choi, Eun Ji, Cho, Eun Ju, Lee, Yun Bin, Lee, Jeong-Hoon, Yu, Su Jong, Yoon, Jung-Hwan, Kim, Yoon Jun
Format: Artigo
Sprog:Inglês
Udgivet: The Korean Association for the Study of the Liver 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641573/
https://ncbi.nlm.nih.gov/pubmed/32829570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3350/cmh.2019.0056n
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