Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

Resulting from impaired collagen turnover, fibrosis is a hallmark of adipose tissue dysfunction and obesity-associated insulin resistance. Prolidase also known as Peptidase D (PEPD) plays a vital role in collagen turnover by degrading proline-containing dipeptides but its specific functional relevan...

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Bibliografiska uppgifter
I publikationen:Nat Metab
Huvudupphovsmän: Pellegrinelli, V, Rodriguez-Cuenca, S, Rouault, C, Figueroa-Juarez, E, Schilbert, H, Virtue, S, Moreno-Navarrete, JM, Bidault, G, Vázquez-Borrego, MC, Dias, AR, Pucker, B., Dale, M, Campbell, M, Carobbio, S, Lin, YH, Vacca, M., Aron-Wisnewsky, J, Mora, S, Masiero, MM, Emmanouilidou, A, Mukhopadhyay, S, Dougan, G, den Hoed, M, Loos, R JF, Fernández-Real, JM, Chiarugi, D, Clément, K, Vidal-Puig, A
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2022
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617220/
https://ncbi.nlm.nih.gov/pubmed/35478031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-022-00561-5
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