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Transition of Metastable Cross-α Crystals into Cross-β Fibrils by β-Turn Flipping
The ensemble of native, folded state was once considered to represent the global energy minimum of a given protein sequence. More recently, the discovery of the cross-β amyloid state revealed that deeper energy minima exist, often associated with pathogenic, fibrillar deposits, when the concentratio...
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| Publicado no: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7616934/ https://ncbi.nlm.nih.gov/pubmed/30532955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b10289 |
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