Podoplanin-expressing macrophages promote lymphangiogenesis and lymphoinvasion via Galectin 8-mediated adhesion to tumor lymphatics

Among tumor-infiltrating immune cells, the highest expression of Podoplanin (PDPN) is found in a subset of tumor-associated macrophages (TAMs). We hereby demonstrate that PDPN is involved in the attachment of this TAM subset to lymphatic endothelial cells (LECs). Mechanistically, PDPN promotes β1 in...

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Udgivet i:Cell Metab
Main Authors: Bieniasz-Krzywiec, Paweł, Martín-Pérez, Rosa, Ehling, Manuel, García-Caballero, Melissa, Pinioti, Sotiria, Pretto, Samantha, Kroes, Roel, Aldeni, Chiara, Matteo, Mario Di, Prenen, Hans, Tribulatti, María Virginia, Campetella, Oscar, Smeets, Ann, Noel, Agnes, Floris, Giuseppe, Van Ginderachter, Jo A., Mazzone, Massimiliano
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616630/
https://ncbi.nlm.nih.gov/pubmed/31447322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.07.015
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