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The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences

Alzheimer disease has a sex bias, with women twice as likely as men to be affected. Studies have linked elevated follicle-stimulating hormone (FSH) levels to worsened Alzheimer disease pathology and cognitive decline in mice. FSH interacts with APOE4, uncovering new aspects of Alzheimer disease. The...

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Pubblicato in:Nat Rev Endocrinol
Autori principali: Sauvé, Florent, Kacimi, Loïc, Prévot, Vincent
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2024
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616426/
https://ncbi.nlm.nih.gov/pubmed/38514817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41574-024-00981-1
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