Neutralizing Autoantibodies Against IL-10 in Inflammatory Bowel Disease

We discovered high titer neutralizing autoantibodies against interleukin-10 (anti-IL-10) in a child with infantile onset IBD, phenocopying inborn errors of IL-10 signalling. Following B cell depletion and associated decline in the anti-IL-10 titer, conventional IBD therapy could be withdrawn. A seco...

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Vydáno v:N Engl J Med
Hlavní autoři: Griffin, Helen, Ceron-Gutierrez, Lourdes, Gharahdaghi, Nima, Ebrahimi, Soraya, Davies, Sophie, Loo, Peh Sun, Szabo, Andras, Williams, Eleri, Mukhopadhyay, Anirban, McLoughlin, Louise, Irwin, Steven, Travis, Simon, Klenerman, Paul, Bunn, Su, Cant, Andrew J., Hambleton, Sophie, Uhlig, Holm H., Doffinger, Rainer
Médium: Artigo
Jazyk:Inglês
Vydáno: 2024
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616361/
https://ncbi.nlm.nih.gov/pubmed/39083772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2312302
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