The radical impact of oxygen on prokaryotic evolution—enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third

Molecular oxygen is a stable diradical. All O(2)-dependent enzymes employ a radical mechanism. Generated by cyanobacteria, O(2) started accumulating on Earth 2.4 billion years ago. Its evolutionary impact is traditionally sought in respiration and energy yield. We mapped 365 O(2)-dependent enzymatic...

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Detalhes bibliográficos
Publicado no:FEBS Lett
Main Authors: Mrnjavac, Natalia, Nagies, Falk S. P., Wimmer, Jessica L. E., Kapust, Nils, Knopp, Michael R., Trost, Katharina, Modjewski, Luca, Bremer, Nico, Mentel, Marek, Esposti, Mauro Degli, Mizrahi, Itzhak, Allen, John F., Martin, William F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2024
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616280/
https://ncbi.nlm.nih.gov/pubmed/38750628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.14906
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