Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

INTRODUCTION: COVID-19 became a global pandemic partially as a result of the lack of easily deployable, broad-spectrum oral antivirals, which complicated its containment. Even endemically, and with effective vaccinations, it will continue to cause acute disease, death, and long-term sequelae globall...

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Vydáno v:Science
Hlavní autoři: Boby, Melissa L., Fearon, Daren, Ferla, Matteo, Filep, Mihajlo, Koekemoer, Lizbé, Robinson, Matthew C., Chodera, John D., Lee, Alpha A., London, Nir, von Delft, Annette, von Delft, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: 2023
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615835/
https://ncbi.nlm.nih.gov/pubmed/37943932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abo7201
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