Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia

During hypoxia, increases in cerebral blood flow maintain brain oxygen delivery. Here, we describe a mechanism of brain oxygen sensing that mediates the dilation of intraparenchymal cerebral blood vessels in response to reductions in oxygen supply. In vitro and in vivo experiments conducted in roden...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Christie, Isabel N., Theparambil, Shefeeq M., Braga, Alice, Doronin, Maxim, Hosford, Patrick S., Brazhe, Alexey, Mascarenhas, Alexander, Nizari, Shereen, Hadjihambi, Anna, Wells, Jack A., Hobbs, Adrian, Semyanov, Alexey, Abramov, Andrey Y., Angelova, Plamena R., Gourine, Alexander V.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2023
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615749/
https://ncbi.nlm.nih.gov/pubmed/38041814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2023.113514
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