The evolutionary divergence of receptor guanylyl cyclase C has implications for preclinical models for receptor-directed therapeutics

Mutations in receptor guanylyl cyclase C (GC-C) cause severe gastrointestinal disease, including meconium ileus, early onset acute diarrhea, and pediatric inflammatory bowel disease that continues into adulthood. Agonists of GC-C are US Food and Drug Administration-approved drugs for the treatment o...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Mishra, Vishwas, Sharma, Kritica, Bose, Avipsa, Maisonneuve, Pierre, Visweswariah, Sandhya S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2023
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615481/
https://ncbi.nlm.nih.gov/pubmed/38029963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2023.105505
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