Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus

BACKGROUND: The appropriate antibiotic treatment for severe scrub typhus, a neglected but widespread reemerging zoonotic infection, is unclear. METHODS: In this multicenter, double-blind, randomized, controlled trial, we compared the efficacy of intravenous doxycycline, azithromycin, or a combinatio...

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Published in:N Engl J Med
Main Authors: Varghese, G.M., Dayanand, D., Gunasekaran, K., Kundu, D., Wyawahare, M., Sharma, N., Chaudhry, D., Mahajan, S.K., Saravu, K., Aruldhas, B.W., Mathew, B.S., Nair, R.G., Newbigging, N., Mathew, A., Abhilash, K.P.P., Biswal, M., Prasad, A.H., Zachariah, A., Iyadurai, R., Hansdak, S.G., Sathyendra, S., Sudarsanam, T.D., Prakash, J.A.J., Manesh, A., Mohan, A., Tarning, J., Blacksell, S.D., Peerawaranun, P., Waithira, N., Mukaka, M., Cheah, P.Y., Peter, J.V., Abraham, O.C., Day, N.P.J.
Format: Artigo
Language:Inglês
Published: 2023
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614458/
https://ncbi.nlm.nih.gov/pubmed/36856615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2208449
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