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Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade

Non-human animal studies outline precise mechanisms of central mu-opioid regulation of pain, stress, affiliation and reward processing. In humans, pharmacological blockade with non-selective opioid antagonists such as naloxone and naltrexone is typically used to assess involvement of the mu-opioid s...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Trøstheim, Martin, Eikemo, Marie, Haaker, Jan, Frost, J. James, Leknes, Siri
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2022
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613944/
https://ncbi.nlm.nih.gov/pubmed/35978096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-022-01416-z
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